In this wild west-themed sequel to Give Me the Brain,Players assume the role of zombies attempting to rob a speeding train full of brains. As the players move forward through the carriages, you can choose to take a brain or government cheese. To win the game, you need to find the Brain with the highest IQ before the Train comes to a stop, and defend it from all the other Zombies who'd rather beat you up than find a better Brain on their own.